Population
Distal nephron cell line (A6) cultured on permeable supports
Comparison
Insulin pretreatment or alkaline phosphatase… vs Cells under similar conditions without insulin…
Design
Preclinical
Authors
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Should not change clinical practice in renal disorders; leaves open insulin modulation of Ca2+-dependent Cl- channels in distal nephron.
Insulin modulates the sensitivity of Ca2+-dependent Cl- channels to cytosolic Ca2+ in distal nephron cells, likely by promoting dephosphorylation.
Marunaka et al. (1990) studied this question.
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