Population
Dissociated myoblasts from 12-day chick embryos cultured in monolayer
Comparison
In vitro differentiation in monolayer culture vs In vivo developing muscle
Design
Preclinical
Authors
Loading...
Muscle develops mature ultrastructure without nerves in vitro; leaves open innervation requirements for human myogenesis and warrants further in vivo validation.
This study demonstrates that embryonic skeletal muscle cells can fully develop their characteristic ultrastructure in vitro without neural innervation.
Shimada et al. (1967) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: