What question did this study set out to answer?

To characterize the acute structural, ultrastructural, and enzymatic alterations in rat liver parenchymal cells following oral carbon tetrachloride administration.

October 1, 1963The Journal of Cell Biology

Liver Parenchymal Cell Injury

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To characterize the acute structural, ultrastructural, and enzymatic alterations in rat liver parenchymal cells following oral carbon tetrachloride administration.
Administered a single oral dose of carbon tetrachloride to rats.
Evaluated liver parenchymal cell alterations across 30-minute to 2-hour intervals using electron microscopy.
Assayed hepatic enzyme activities, including glucose-6-phosphatase, succinic dehydrogenase, and glutamic dehydrogenase, alongside intracellular calcium tracking.
Within 1 hour, electron microscopy demonstrated cisternae vacuolization and membrane degranulation of the granular endoplasmic reticulum, mitochondrial enlargement and fusion, and Golgi vesicle swelling.
Parenchymal cell calcium influx commenced by 30 minutes, peaked at 1 hour with mitochondrial sequestration, and normalized by 2 hours.
Progressive loss of glucose-6-phosphatase activity accompanied ergastoplasm dispersal, whereas succinic and glutamic dehydrogenase lobular patterns remained unaffected.

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Implication

Experimental study demonstrates rapid organelle disruption and calcium influx in rat liver parenchymal cells, suggesting direct membrane toxicity from carbon tetrachloride.

Cite This Study

Edward S. Reynolds (1963) studied this question.

synapsesocial.com/papers/6a87127bd75f6552a082baa8 https://doi.org/10.1083/jcb.19.1.139

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Implication

Experimental study demonstrates rapid organelle disruption and calcium influx in rat liver parenchymal cells, suggesting direct membrane toxicity from carbon tetrachloride.

Liver Parenchymal Cell Injury

Key Points

Discussion

Implication

Cite This Study

Liver Parenchymal Cell Injury

Key Points

Discussion

Implication

Cite This Study

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