Key result
Carbon tetrachloride poisoning markedly reduces plasma triglyceride accumulation in rats by impairing hepatic secretion.
Why the study?
The mechanism by which carbon tetrachloride affects hepatic triglyceride secretion and causes fat infiltration was unclear.
May implicate hepatic triglyceride secretion defects in toxin models; leaves open translation to human dyslipidemia.
Intravenous administration of Triton to rats causes a marked elevation of plasma triglycerides. If the rats have been poisoned with carbon tetrachloride 2 hours previously, accumulation of triglycerides in the plasma following Triton administration is markedly reduced. The existence of an hepatic triglyceride secretory mechanism is inferred from the work of others, and it is postulated that carbon tetrachloride poisons this triglyceride secretory mechanism. Triglycerides, which would normally be secreted into plasma, are retained in the liver.
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Recknagel et al. (1960) studied Carbon tetrachloride fat infiltration. Carbon tetrachloride vs. Triton administration alone was evaluated on Plasma triglyceride accumulation. Carbon tetrachloride poisoning prior to Triton administration markedly reduced plasma triglyceride accumulation in rats, suggesting impairment of the hepatic triglyceride secretory mechanism.
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