Key result
Surgical resection of a large right adrenal mass in a 47-year-old woman presenting with abdominal fullness confirmed the diagnosis of primary adrenal angiosarcoma.
Why the study?
Adrenal angiosarcoma is a rare and aggressive malignancy with nonspecific symptoms that make early detection challenging, and standardized treatment guidelines are lacking.
Case Report (n=1)
This case highlights the diagnostic challenges and importance of early surgical intervention for primary adrenal angiosarcoma, an exceedingly rare and aggressive malignancy.
Emphasizes diagnostic challenges in rare adrenal angiosarcoma; leaves open need for validated protocols in visceral vascular tumors.
This case discusses the challenges of diagnosing adrenal angiosarcoma, a rare and aggressive malignancy that constitutes an exceptionally small proportion of adrenal tumors. Angiosarcomas originate from blood or lymphatic vessel endothelium, with soft tissue and cutaneous forms being more prevalent than those arising in visceral organs such as the adrenal glands. This report describes a 47-year-old female patient who presented with a large right adrenal mass identified through imaging and was subsequently diagnosed with primary adrenal angiosarcoma. This disease may remain asymptomatic or present with nonspecific symptoms, making early detection challenging. Prompt identification and surgical management are essential, as the tumor exhibits a high propensity for aggressive behavior and metastatic spread. While no standardized treatment guidelines exist, adrenalectomy and systemic therapy are commonly employed strategies. Prognosis remains unfavorable, often influenced by tumor size, necrosis, and metastatic involvement at diagnosis. This case highlights the importance of accurate diagnostic methods and early intervention to enhance patient outcomes.
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Echeverría-Ortegón et al. (2025) conducted a case report in Adrenal angiosarcoma (n=1). Surgical resection (adrenalectomy) was evaluated. Surgical resection of a large right adrenal mass in a 47-year-old woman presenting with abdominal fullness confirmed the diagnosis of primary adrenal angiosarcoma.
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