Key result
A 34-year-old patient presented with a rare association of an ACTH-secreting pituitary adenoma and an adrenal spindle cell angiosarcoma, which complicated the diagnosis of Cushing's disease.
Case Report (n=1)
This case highlights the diagnostic challenges of Cushing's disease when associated with a rare adrenal angiosarcoma.
Rare dual pathology may obscure Cushing's diagnosis; single case report extends literature but leaves broader implications open.
The occurrence of an angiosarcoma in the adrenal gland is exceedingly rare as only 21 patients have been reported in the literature since its first description 30 years ago. We report the clinicopathological features of a 34-year-old patient presenting with overt Cushing's syndrome due to a ACTH-secreting pituitary adenoma and an adrenal spindle cell angiosarcoma. This association made the diagnosis of Cushing's disease particularly puzzling in view of the results of biochemical tests which were compatible in part with adrenal and in part with paraneoplastic hypercortisolism and the negative pituitary imaging. The unique appearance of this tumor and its diagnostic implications are discussed.
No takes yet. Share an insight, caveat, or question.
Invitti et al. (2001) conducted a case report in Cushing's disease and adrenal spindle cell angiosarcoma (n=1). Adrenal spindle cell angiosarcoma and ACTH-secreting pituitary adenoma was evaluated. A 34-year-old patient presented with a rare association of an ACTH-secreting pituitary adenoma and an adrenal spindle cell angiosarcoma, which complicated the diagnosis of Cushing's disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: