Key result
A 35-year-old man with a rare combined primary adrenal angiosarcoma and functioning adrenocortical adenoma was successfully treated with surgery and chemotherapy, remaining relapse-free at 2 years.
Case Report (n=1)
This is the first reported case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma, successfully treated with surgery and chemotherapy.
Adds novel entity to adrenal mass differential; leaves open optimal therapy and pathogenesis for combined angiosarcoma-adenoma.
CONTEXT: Primary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion. CLINICAL PRESENTATION AND INTERVENTION: A 35-year-old man presented with hypokalemic hypertension leading to the discovery of a 6 cm diameter malignant-appearing right adrenal tumor. The lesion displayed marked (18)F-fluorodeoxyglucose uptake on positron emission tomography scanning. Endocrine investigations revealed secretion of both cortisol and aldosterone by the neoplasm. The entire right adrenal gland along with the periadrenal fat tissue was removed during laparoscopic surgery. RESULTS: Histological examination revealed two intermingled tumor cell proliferations, namely an angiosarcoma and an adrenocortical adenoma. An extensive post-operative search revealed no other primary tumor site, nor metastases. The lesion was then considered to be a primary adrenal angiosarcoma combined with a secreting adrenocortical adenoma. The patient received four cycles of chemotherapy (adriamycin/ifosfamide). At 2-year follow-up, he is alive and well, with no sign of relapse. CONCLUSION: To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma.
No takes yet. Share an insight, caveat, or question.
Rousseau et al. (2011) conducted a case report in Primary adrenal angiosarcoma and functioning adrenocortical adenoma (n=1). Laparoscopic surgery and chemotherapy (adriamycin/ifosfamide) was evaluated on Survival and relapse. A 35-year-old man with a rare combined primary adrenal angiosarcoma and functioning adrenocortical adenoma was successfully treated with surgery and chemotherapy, remaining relapse-free at 2 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: