Why the study?
Does ouabain induce its positive inotropic effect via the bumetanide-sensitive Na+/K+/Cl- cotransporter in cultured rat cardiac myocytes?
Population
Cultured rat cardiac myocytes
Comparison
Ouabain (10 M) with or without bumetanide or… vs Basal conditions / no treatment
Design
Preclinical
Authors
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Hypothesis-generating for ouabain inotropy in rat myocytes; leaves open relevance to human cardiac glycoside therapy.
Does ouabain induce its positive inotropic effect via the bumetanide-sensitive Na+/K+/Cl- cotransporter in cultured rat cardiac myocytes?
Ouabain induces a positive inotropic effect in rat cardiac myocytes by stimulating Na+ influx through the bumetanide-sensitive Na+/K+/Cl- cotransporter.
Panet et al. (1990) studied this question.
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