Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion

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Population

Pure cell isolate from a heterocellular organ (gastric epithelium) and isolated gastric glands

Design

Preclinical

Authors

Discussion

May support novel acid-suppressive targets; leaves open in vivo efficacy and human translation.

Population

Pure cell isolate from a heterocellular organ (gastric epithelium) and isolated gastric glands

Intervention

Specific KCNQ inhibitors

Outcome

Inhibition of acid secretion and colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cellsurrogate

KCNQ1-KCNE2 is identified as the essential K efflux channel coupled to the gastric H-K-ATPase for gastric acid secretion.

Lambrecht et al. (2004) studied this question.

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