Key result
In nonsecreting parietal cells, KCNJ15 is stored in vesicles distinct from H-K-ATPase-enriched tubulovesicles, and upon stimulation, both translocate to the apical membrane for active acid secretion.
Population
Gastric mucosa, liver tissue, isolated gastric glands, and parietal cells
Comparison
Stimulation of parietal cells vs Resting (nonsecreting) parietal cells
Design
Preclinical
Authors
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KCNJ15 may support stimulated acid secretion in rodent parietal cells; leaves open its human relevance and therapeutic potential.
The study identifies KCNJ15 as an apical potassium channel in gastric parietal cells that translocates to the apical membrane upon stimulation to support acid secretion.
He et al. (2011) studied this question. Histamine/IBMX stimulation vs. Resting state (cimetidine) was evaluated on KCNJ15 expression and subcellular localization. In nonsecreting parietal cells, KCNJ15 is stored in vesicles distinct from H-K-ATPase-enriched tubulovesicles, and upon stimulation, both translocate to the apical membrane for active acid secretion.
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