Key result
Central aortic blood pressure, particularly central pulse pressure, was significantly associated with electrocardiographic indices of left ventricular hypertrophy (p=0.0085), unlike brachial blood pressure.
Why the study?
Evidence suggests central aortic blood pressure is more associated with left ventricular myocardial hypertrophy than brachial blood pressure, motivating a comparison between both measures and electrocardiographic left ventricular hypertrophy.
Do central aortic blood pressure parameters correlate better with electrocardiographic signs of left ventricular hypertrophy than brachial blood pressure in the general population?
Cross-Sectional (n=327)
No
Do central aortic blood pressure parameters correlate better with electrocardiographic signs of left ventricular hypertrophy than brachial blood pressure in the general population?
Central aortic blood pressure parameters are more strongly associated with electrocardiographic signs of left ventricular hypertrophy than brachial blood pressure in a young to middle-aged general population.
Central pulse pressure may better mark ECG LVH than brachial; hypothesis-generating in cross-sectional data, needs prospective validation.
Aim. There is evidence that central aortic blood pressure (BP) is more associated with left ventricular myocardial hypertrophy than brachial BP. The purpose of this work is to compare the association of brachial and central aortic BP with electrocardiographic parameters of left ventricular hypertrophy in the general population of Novosibirsk. Material and methods . We examined 327 people: 155 men and 172 women aged 25-44 years from a representative sample from the general population of Novosibirsk. The study program included anthropometry, BP measurement, electrocardiography, biochemical blood analysis. Radial artery applanation tonometry and pulse wave analysis were performed using the SphygmoCor system. Left ventricular hypertrophy was determined by electrocardiographic parameters. Results. In the general population of Novosibirsk, central aortic BP is more associated with left ventricular myocardial hypertrophy than brachial BP. Central pulse pressure, in contrast to brachial BP, is significantly associated with the R+S index (p=0,0085), as well as RI (p=0,0038) and RaVL (p=0,0039) wave amplitude. Central systolic aortic BP, in contrast to brachial systolic BP, is significantly associated with RI (p=0,042) and RaVL (p=0,029) wave amplitudes. Amplification parameters of central aortic BP, regardless of brachial BP, are associated with indices of left ventricular hypertrophy. Pulse pressure amplification in groups with or without left ventricular hypertrophy, standardized for age, gender, height, waist circumference, heart rate, triglyceride levels, high density lipoprotein cholesterol, low density lipoprotein cholesterol, blood glucose, and brachial pulse pressure, was 13,3 mm Hg and 12,5 mm Hg, respectively (p=0,035). Conclusion. The results of this study substantiate the relevance of the practical use of central aortic BP parameters in addition to the office measurement of brachial BP.
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Tsvetkova et al. (2019) conducted a cross-sectional in Left ventricular hypertrophy (n=327). Central aortic blood pressure vs. Brachial blood pressure was evaluated on Association of central pulse pressure with RI+SIII index of left ventricular hypertrophy (p=0.0085). Central aortic blood pressure, particularly central pulse pressure, was significantly associated with electrocardiographic indices of left ventricular hypertrophy (p=0.0085), unlike brachial blood pressure.
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