March 23, 2010Journal of Hypertension
Efficacy and safety of routine blood pressure lowering in older patients with diabetes: results from the ADVANCE trial
Why the study?
Does perindopril-indapamide reduce the risk of major macrovascular and microvascular disease in older patients with type 2 diabetes?
Population
11,140 patients aged at least 55 years with type 2 diabetes (mean age 66+/-6 years)
Comparison
Perindopril-indapamide vs Placebo
Design
RCT, Randomly assigned
Follow-up
mean 4.3 years
Authors
Discussion
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Member takes
Implication
Supports routine perindopril-indapamide in older type 2 diabetes patients; confirms consistent relative benefits across ages.
Structured PICO
Does perindopril-indapamide reduce the risk of major macrovascular and microvascular disease in older patients with type 2 diabetes?
P
Population
11,140 patients aged at least 55 years with type 2 diabetes (mean age 66+/-6 years)
I
Intervention
Perindopril-indapamide
C
Comparator
Placebo
O
Outcome
Composite of major macrovascular and microvascular diseasecomposite
Routine blood pressure lowering with perindopril-indapamide safely reduces major clinical outcomes in older patients with type 2 diabetes, with the greatest absolute benefit seen in those aged 75 years and older.
Cite This Study
Ninomiya et al. (2010) studied this question.