Key result
mRNA deadenylation mediated by the CCR4-NOT complex prevents Atg7-induced cell death and heart failure by modulating p53 activity in cardiomyocytes.
Why the study?
Does the CCR4-NOT deadenylase complex prevent Atg7-induced cell death and heart failure in cardiomyocytes?
Population
Cardiomyocytes and heart tissue models
Design
Preclinical
Authors
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Does not support clinical use; leaves open whether CCR4-NOT modulation could mitigate heart failure.
Does the CCR4-NOT deadenylase complex prevent Atg7-induced cell death and heart failure in cardiomyocytes?
The CCR4-NOT deadenylase complex is essential for maintaining cardiac homeostasis by preventing Atg7- and p53-mediated cardiomyocyte cell death and subsequent heart failure.
Yamaguchi et al. (2018) studied Heart failure. CCR4-NOT deadenylase complex was evaluated on Atg7-induced cell death and heart failure. mRNA deadenylation mediated by the CCR4-NOT complex prevents Atg7-induced cell death and heart failure by modulating p53 activity in cardiomyocytes.
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