Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort

Figures

• 

  Figure 1. Flowchart shows the study selection process. Abbreviations: UA, uric acid; eGFR, estimated glomerular filtration rate. a A malignancy was defined as active cancer or a cancer treatment completed less than one year before the date of registration.

• 

  Figure 2. Scatterplot shows EF (%) as a function of UA (mg/dL). Cases with missing data were excluded; linear regression fit: EF (%) = 56.613 − 1.056 * UA (mg/dL), r = −0.1458.

• 

  Figure 3. A receiver operating characteristic curve shows the prognostic value of UA concentration for predicting which patients will have an ejection fraction < 40%. The cutoff value (6.69 mg/dL) was identified with the Youden index method. AUC: area under the curve.

• 

  Figure 4. Scatterplots with error bars for comparison of groups, based on median UA concentration (6.43 mg/dL), as far as fallowing variables are concerned: (A) eGFR, (B) UA concentration, (C) EF, (D) LDL concentration, (E) TC concentration, (F) TG concentration, (G) HDL concentration. Abbreviations: UA, uric acid; EF, ejection fraction; eGFR, estimated glomerular filtration rate; TC, total cholesterol; LDL, low-density lipoproteins; TG, triglycerides; HDL, high-density lipoproteins; CI, confidence interval.

• 

  Figure 5. Comparison of groups, based on median UA concentration (6.43 mg/dL), as far as EF, diuretics usage and type of AF are concerned. Abbreviations: UA, uric acid; atrial fibrillation; EF, ejection fraction; ARA, aldosterone receptor antagonists; diuretics stands for: any and all diuretics, including ARA or/and loop diuretics.

• 

  Figure 6. Results of univariate logistic regression for permanent AF and UA cutoff value (6.69 mg/dL). Abbreviations: AF, atrial fibrillation; UA, uric acid; OR, odds ratio; CI, confidence interval.

• 

  Figure 7. Results of univariate logistic regression for all groups of drugs. Abbreviations: BB, beta-blockers; ACEi, angiotensin converting enzyme inhibitors; ARB, angiotensin receptor blockers; ARA, aldosterone receptor antagonists; OR, odds ratio; CI, confidence interval. Diuretics: any and all diuretics, including ARA or/and loop diuretics.