Why the study?
The association between resting heart rate and hypertension in adults was unclear.
Does higher resting heart rate increase the risk of incident hypertension in adults?
Does higher resting heart rate increase the risk of incident hypertension in adults?
There is a linear dose-response association between higher resting heart rate and an increased risk of incident hypertension in adults.
Supports RHR as hypertension risk marker in adults; leaves open whether modification reduces incidence.
BACKGROUND: The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association. METHODS: We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship. RESULTS: Nine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06-1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55.5 beats per minute, the risk of hypertension significantly increased with increasing levels of RHR (Pnonlinearity = 0.059). CONCLUSION: We found a linear dose-response association between RHR and incident hypertension in adults.
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Shen et al. (2020) studied this question.
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