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January 23, 2007Circulation

Prognostic Value of Heart Rate Increase at Onset of Exercise Testing

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Why the study?

Does the heart rate increase at the onset of exercise testing predict mortality in patients referred for routine clinical treadmill testing?

Population

1959 patients referred for clinical treadmill testing at the Palo Alto Veterans Affairs Medical Center from…

Design

Cohort

Follow-up

mean 5.4+/-2.1 years

Authors

NLNicholas J. LeeperFDFrederick E. DeweyEAEuan A. Ashley

Discussion

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Overview

May enhance risk stratification in routine treadmill testing; leaves open incremental value beyond peak HR and Duke score.

Structured PICO

Does the heart rate increase at the onset of exercise testing predict mortality in patients referred for routine clinical treadmill testing?

P
Population
1959 patients referred for clinical treadmill testing at the Palo Alto (Calif) Veterans Affairs Medical Center from 1997 to 2004.
I
Intervention
Heart rate increase at onset of exercise testing (specifically at one-third total exercise capacity)
O
Outcome
All-cause mortality and cardiovascular mortalityhard clinical

A rapid initial heart rate rise during treadmill testing predicts improved survival, though peak heart rate increase and the Duke treadmill score are more powerful prognostic predictors.

Cite This Study

Leeper et al. (2007) studied this question.

synapsesocial.com/papers/6a871af4bb0787ff27ca1a04https://doi.org/10.1161/circulationaha.106.666388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired Heart Rate Response to Graded Exercise1996 · 533 citations
  2. 2Predictive implications of stress testing. Follow-up of 2700 subjects after maximum treadmill stress testing.1975 · 461 citations
  3. 3"Recovery Only" ST-Segment Depression and the Predictive Accuracy of the Exercise Test1990 · 96 citations
  4. 4Cardiovascular responses to exercise as functions of absolute and relative work load1983 · 190 citations
  5. 5Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction1998 · 3,124 citations