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Many of the substrates of the hepatic microsomal cytochrome P-450 enzyme system are powerful inducers of the enzyme. Pretreatment of animals with these substrates leads to an increase in overall enzyme activity associated with increases in microsomal protein, cytochrome P-450 and NADPH-cytochrome P-450 reductase activity. We have investigated some of the factors that are responsible for the maintenance of normal enzyme activity and for the control of the response of the enzyme system to inducers.
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Marshall et al. (1969) studied this question.
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