Why the study?
What is the earliest and most reliable hemodynamic or blood gas parameter to indicate blood loss in a canine model?
Population
16 mongrel dogs, anesthetized
Design
Preclinical
Authors
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SvO2 tracks blood loss more linearly than CI in canines; leaves open human validation.
What is the earliest and most reliable hemodynamic or blood gas parameter to indicate blood loss in a canine model?
Mixed venous oxygen saturation is a highly reliable and early indicator of blood loss, outperforming cardiac index and heart rate in a canine hemorrhage model.
Scalea et al. (1986) studied this question.