Molecular analysis confirming the SYT-SSX2 fusion transcript aids in the diagnosis of extremely rare synovial sarcoma of the tongue.
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May aid diagnosis of rare tongue synovial sarcoma; leaves open validation in larger cohorts.
Involvement of the tongue by a synovial sarcoma (SS) is an extremely rare event; there have only been 13 cases previously reported. The authors present herein a case of monophasic SS arising in the tongue in a 32-year-old woman. The neoplasm expressed cytokeratins AE1-3, OSCAR, and EMA as well as Bcl-2 and TLE1. Molecular analysis indicated that the patient tested positive for the SYT/SS2 fusion transcript.
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Villaroel-Salinas et al. (2011) studied this question.
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