What question did this study set out to answer?

To determine whether inadequate control for preexisting illness or cigarette smoking explains the observed association between weight loss and increased mortality risk.

October 1, 1993Annals of Internal Medicine

Weight Loss and Subsequent Death in a Cohort of U.S. Adults

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Authors

EPElsie R. PamukUniversity of North Carolina at Chapel Hill

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Implication

Cohort study finds weight loss increases cardiovascular mortality risk in older adults, indicating preexisting illness alone does not explain the association.

Key Points

To determine whether inadequate control for preexisting illness or cigarette smoking explains the observed association between weight loss and increased mortality risk.
Cohort study analyzing data from the first National Health and Nutrition Examination Survey (NHANES I, 1971–1975) linked to the Epidemiologic Follow-up Study through 1987.
Evaluated 2,453 men and 2,739 women aged 45 to 74 years with baseline data on maximum lifetime weight and measured current weight.
Excluded individuals dying within the first 5 and 8 years of follow-up to reduce reverse causality from preexisting disease, with stratified sensitivity analyses by smoking status.
Exclusion of deaths occurring within 5 and 8 years of baseline weakened the association between weight loss and noncardiovascular mortality in women.
Excluding deaths for up to 8 years did not diminish the association with cardiovascular death in participants with maximum BMI 26 to 29 kg/m², yielding relative risks of up to 2.1 in men and 3.6 in women.
Restricting analyses to participants who had never smoked did not substantially alter the risk associations between weight loss and mortality.

Cite This Study

Elsie R. Pamuk (1993) studied this question.

synapsesocial.com/papers/6a87228ec026610cc182d615 https://doi.org/10.7326/0003-4819-119-7_part_2-199310011-00023

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Implication

Cohort study finds weight loss increases cardiovascular mortality risk in older adults, indicating preexisting illness alone does not explain the association.

Weight Loss and Subsequent Death in a Cohort of U.S. Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

Weight Loss and Subsequent Death in a Cohort of U.S. Adults

Discussion

Member takes

Implication

Key Points

Cite This Study

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