What question did this study set out to answer?

To determine the relationship between body weight, assessed via body mass index (BMI), and all-cause mortality.

December 15, 1993JAMA

Body Weight and Mortality

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Authors

ILI-Min LeeBrigham and Women's Hospital

Discussion

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Implication

Prospective cohort study demonstrates a direct relation between body weight and mortality in men, indicating lean individuals have the lowest death risk.

Key Points

To determine the relationship between body weight, assessed via body mass index (BMI), and all-cause mortality.
Prospective cohort study following 19,297 Harvard alumni (mean age 46.6 years in 1962/1966) free of baseline coronary heart disease, stroke, or cancer through 1988.
Questionnaires assessed self-reported height, weight, smoking habits, and physical activity to examine 4,370 all-cause mortality events.
Subgroup analyses were performed by restricting the cohort to never-smokers and excluding the first 5 years of follow-up to control for confounding and reverse causation.
Multivariate analysis adjusted for age, smoking, and physical activity initially showed a J-shaped curve, with relative risks across BMI tiers (<22.5, 22.5–<23.5, 23.5–<24.5, 24.5–<26.0, ≥26.0) of 1.00 (referent), 0.99 (95% CI, 0.89–1.20), 0.95 (95% CI, 0.87–1.05), 1.01 (95% CI, 0.91–1.10), and 1.18 (95% CI, 1.08–1.28; P for linear trend = .0008).
Restricting analysis to never-smokers and excluding the first 5 years of follow-up revealed a direct positive relation, with relative risks of 1.00 (referent), 1.23 (95% CI, 0.90–1.67), 1.06 (95% CI, 0.80–1.42), 1.27 (95% CI, 0.96–1.68), and 1.67 (95% CI, 1.29–2.17; P for linear trend = .0001).

Cite This Study

I-Min Lee (1993) studied this question.

synapsesocial.com/papers/6a101a9290ecb39bf65fc625 https://doi.org/10.1001/jama.1993.03510230061036

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December 15, 1993JAMA

Body Weight and Mortality

View Full Paper

Ask AI

Bookmark

Authors

ILI-Min LeeBrigham and Women's Hospital

Discussion

Member takes

Implication

Prospective cohort study demonstrates a direct relation between body weight and mortality in men, indicating lean individuals have the lowest death risk.

Key Points

To determine the relationship between body weight, assessed via body mass index (BMI), and all-cause mortality.
Prospective cohort study following 19,297 Harvard alumni (mean age 46.6 years in 1962/1966) free of baseline coronary heart disease, stroke, or cancer through 1988.
Questionnaires assessed self-reported height, weight, smoking habits, and physical activity to examine 4,370 all-cause mortality events.
Subgroup analyses were performed by restricting the cohort to never-smokers and excluding the first 5 years of follow-up to control for confounding and reverse causation.
Multivariate analysis adjusted for age, smoking, and physical activity initially showed a J-shaped curve, with relative risks across BMI tiers (<22.5, 22.5–<23.5, 23.5–<24.5, 24.5–<26.0, ≥26.0) of 1.00 (referent), 0.99 (95% CI, 0.89–1.20), 0.95 (95% CI, 0.87–1.05), 1.01 (95% CI, 0.91–1.10), and 1.18 (95% CI, 1.08–1.28; P for linear trend = .0008).
Restricting analysis to never-smokers and excluding the first 5 years of follow-up revealed a direct positive relation, with relative risks of 1.00 (referent), 1.23 (95% CI, 0.90–1.67), 1.06 (95% CI, 0.80–1.42), 1.27 (95% CI, 0.96–1.68), and 1.67 (95% CI, 1.29–2.17; P for linear trend = .0001).

Cite This Study

I-Min Lee (1993) studied this question.

synapsesocial.com/papers/6a101a9290ecb39bf65fc625 https://doi.org/10.1001/jama.1993.03510230061036

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