Why the study?
Does the addition of low-dose quinidine to propafenone increase propafenone plasma concentrations and prevent recurrence of atrial fibrillation in patients with atrial fibrillation?
Does the addition of low-dose quinidine to propafenone increase propafenone plasma concentrations and prevent recurrence of atrial fibrillation in patients with atrial fibrillation?
Low-dose quinidine effectively inhibits CYP2D6 to increase propafenone plasma levels, which is associated with improved maintenance of sinus rhythm in patients with atrial fibrillation.
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Supports pharmacokinetic enhancement of propafenone with quinidine for AF maintenance; extends role of CYP2D6 inhibitors in antiarrhythmic dosing.
O’Hara et al. (2011) studied this question.
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