Why the study?
Improving the long-term impact of permanent coronary stents remains a challenge after disappointing trials with bioresorbable vascular scaffolds.
The DESolve novolimus bioresorbable scaffold offers unique self-correction properties and complete dissolution within 2 years, presenting a potential advancement in bioresorbable vascular scaffolds.
DESolve may revive bioresorbable scaffold interest; leaves open whether it improves long-term outcomes over metallic DES.
A longtime aspiration of interventional cardiologists remains to improve the long-term impact of stent permanence in coronaries to restore original vessel patency and physiological endothelium response. Bioresorbable vascular scaffolds were considered revolutionary in coronary devices, but several trials were disappointing; thus, the challenge in this field remains. DESolve is a novolimus-eluting poly-L-lactide-based polymer scaffold that dissolves through a bio-reabsorption mechanism, vanishing completely in 2 years. Its ability to supply the necessary radial strength to support the vessel for the critical early months after delivery is an important feature showing a unique self-correction property, which reduces incomplete stent apposition. Overexpansion has a good, safe margin with DESolve. This review aims to provide an overview of this controversial topic.
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Demola et al. (2021) studied this question.
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