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December 29, 2022Egyptian Journal of Medical Human GeneticsOpen Access

Interactions dietary components with expression level of breast cancer-related genes

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Authors

FBFatemeh BourbourAPAzam PourtaheriKAKhadijeh Abbasi

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Overview

Narrative review reveals that specific dietary factors regulate breast cancer gene expression in at-risk populations, highlighting targeted nutrition as a potential strategy to reduce risk.

Key Points

  • To evaluate how specific dietary components and nutritional habits influence the expression levels of genes associated with breast cancer risk and progression.
  • Conducted a narrative review across Embase, PubMed, PsycInfo, and Cochrane databases.
  • Identified studies examining interactions between breast cancer, genetic alterations, gene expression, and dietary intake.
  • Moderate vitamin B12 supplementation showed protective potential against breast cancer among carriers of inherited BRCA mutations.
  • Olive oil intake demonstrated protective associations against breast cancer, partially by suppressing HER2 expression.
  • High glycemic index foods increased breast cancer risk through activation of the PI3K/AKT pathway and up-regulation of FTO gene expression.

Cite This Study

Bourbour et al. (2022) studied this question.

synapsesocial.com/papers/6a87293ca810ea404bcfad7fhttps://doi.org/10.1186/s43042-022-00375-w
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