Population
Yeast model using a closely related set of cat mRNAs
Comparison
Introduction of 5'-secondary structures at… vs cat mRNA with unstructured 5'-leader
Design
Preclinical
Authors
Loading...
Hypothesis-generating for mRNA translation control; leaves open relevance to cardiovascular gene expression pending mammalian studies.
In yeast, 5'-secondary structures in mRNA inhibit translation initiation by causing a biphasic polysome distribution, suggesting 40S ribosomal subunits bind early in the scanning process before unwinding.
Sagliocco et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: