Ischemic limb gangrene with preserved pulses should raise suspicion for venous thrombosis and procoagulant-anticoagulant imbalances such as protein C deficiency.
Alerts clinicians to venous thrombosis in limb gangrene with preserved pulses; leaves open protein C testing utility pending prospective validation.
A variety of systemic illnesses can be associated with limb gangrene with preservation of arterial pulses. Many such disorders involve venous thrombosis caused by a procoagulant–anticoagulant imbalance often related to low levels of protein C.
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Theodore E. Warkentin (2015) studied this question.
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