Key result
Acquired acral limb ischemia typically involves DIC, anticoagulant depletion, and a localizing factor for microthrombosis.
Why the study?
This historical review traces the recognition of natural anticoagulant depletion, initially established in nonacral ischemic syndromes, as also being a key feature of predominantly acral ischemic microthrombosis syndromes such as venous limb gangrene and symmetrical peripheral gangrene.
Acquired acral limb ischemic syndromes like venous limb gangrene and symmetrical peripheral gangrene typically involve a triad of disseminated intravascular coagulation, natural anticoagulant depletion, and a localizing factor such as DVT or circulatory shock.
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Supports triad evaluation in acral ischemia; leaves open prospective trials to guide therapy.
Theodore E. Warkentin (2024) conducted a review in Venous limb gangrene and symmetrical peripheral gangrene. Natural anticoagulant depletion was evaluated. Acquired acral limb ischemic syndromes typically involve the triad of disseminated intravascular coagulation, natural anticoagulant depletion, and a localizing factor for microthrombosis.
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