Key result
Symmetrical peripheral gangrene in critically ill patients is likely caused by microvascular thrombosis due to failure of natural anticoagulant systems following shock liver, rather than vasopressors.
Why the study?
Relatively little scientific attention has been given to the small subset of critically ill patients with circulatory shock who develop ischaemic limb losses (symmetrical peripheral gangrene).
Ischaemic limb loss in shock is primarily due to microvascular thrombosis from DIC and shock liver-induced anticoagulant failure, rather than vasopressor use.
No takes yet. Share an insight, caveat, or question.
Questions vasopressor attribution in symmetrical peripheral gangrene; leaves open trials targeting anticoagulant failure after shock liver.
Theodore E. Warkentin (2019) conducted a review in Circulatory shock with ischaemic limb losses (symmetrical peripheral gangrene). Symmetrical peripheral gangrene in critically ill patients is likely caused by microvascular thrombosis due to failure of natural anticoagulant systems following shock liver, rather than vasopressors.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: