What question did this study set out to answer?

To evaluate the effects of zolpidem and zaleplon on sleep architecture, nocturnal respiratory patterns, and subsequent daytime cognitive and physical performance at a simulated altitude of 4,000 m.

January 1, 2004Neuropsychobiology

Effects of Zolpidem and Zaleplon on Sleep, Respiratory Patterns and Performance at a Simulated Altitude of 4,000 m

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Authors

MBMaurice BeaumontNestlé (Switzerland)DBDenise BatéjatInstitut de Médecine Tropicale du Service de Santé des Armées OCOlivier CosteService de Santé de la Jeunesse

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Implication

Placebo-controlled trial reveals zolpidem and zaleplon improve slow wave sleep without impairing respiration or performance at high altitude, indicating safe hypnotic use for climbers.

Key Points

To evaluate the effects of zolpidem and zaleplon on sleep architecture, nocturnal respiratory patterns, and subsequent daytime cognitive and physical performance at a simulated altitude of 4,000 m.
Assessed 12 healthy male participants across 4 nights in a decompression chamber (1 sea-level baseline night, followed by 3 nights at a simulated altitude of 4,000 m).
Administered zolpidem (10 mg), zaleplon (10 mg), and placebo 15 minutes prior to lights out across the altitude nights.
Measured nocturnal sleep and breathing profiles using polysomnography, followed by sea-level cognitive and physical performance testing the following morning.
Both zolpidem and zaleplon significantly improved slow wave sleep at altitude, with zolpidem exhibiting more marked enhancements than zaleplon.
Neither drug adversely impacted overnight respiratory patterns at 4,000 m altitude or decreased cognitive or physical performance metrics the following morning.

Cite This Study

Beaumont et al. (2004) studied this question.

synapsesocial.com/papers/6a873688f87adc0a02ca35d3 https://doi.org/10.1159/000076723

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Implication

Placebo-controlled trial reveals zolpidem and zaleplon improve slow wave sleep without impairing respiration or performance at high altitude, indicating safe hypnotic use for climbers.

Effects of Zolpidem and Zaleplon on Sleep, Respiratory Patterns and Performance at a Simulated Altitude of 4,000 m

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Zolpidem and Zaleplon on Sleep, Respiratory Patterns and Performance at a Simulated Altitude of 4,000 m

Discussion

Member takes

Implication

Key Points

Cite This Study

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