Why the study?
Do acetylcholine infusion and inhaled nitric oxide have different effects on hemodynamics and gas exchange in patients with COLD and pulmonary hypertension?
Population
13 patients with chronic obstructive lung disease (COLD) and pulmonary hypertension
Comparison
Infusion of acetylcholine at 15 mg/min and… vs Baseline values prior to each intervention
Design
Other
Authors
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Inhaled NO may selectively improve hemodynamics and oxygenation in COLD with PH; leaves open its clinical role pending randomized outcome trials.
Do acetylcholine infusion and inhaled nitric oxide have different effects on hemodynamics and gas exchange in patients with COLD and pulmonary hypertension?
In patients with COLD and pulmonary hypertension, inhaled nitric oxide provides selective pulmonary vasodilation and improves gas exchange, unlike acetylcholine which causes systemic vasodilation and impairs oxygenation.
Adnot et al. (1993) studied this question.
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