Why the study?
Does inhalation of nitric oxide improve pulmonary hemodynamics and gas exchange in patients with advanced COPD?
Population
13 patients with advanced chronic obstructive pulmonary disease (COPD)
Comparison
Inhalation of nitric oxide at 40 parts per… vs Breathing room air
Design
Other
Authors
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Caution against inhaled NO in advanced COPD due to oxygenation worsening; leaves open whether selective vasodilators can safely improve hemodynamics.
Does inhalation of nitric oxide improve pulmonary hemodynamics and gas exchange in patients with advanced COPD?
In patients with advanced COPD, inhaled nitric oxide lowers pulmonary artery pressure but worsens arterial oxygenation by impairing hypoxic pulmonary vasoconstriction.
Jones et al. (1997) studied this question.
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