What question did this study set out to answer?

To evaluate the clinical manifestations, risk factors for adverse outcomes, and antiviral treatment efficacy among immunosuppressed inpatients diagnosed with influenza.

January 30, 2024Open Access

Clinical characteristics, risk factors and antiviral treatment of Influenza in immunosuppressed inpatients in Beijing, 2015-2020

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Authors

YLYafen LiuPeking University YWYue WangFlorida State University HMHuan MaiPeking University

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Implication

Cohort study identifies risk factors for critical illness and death from influenza in immunosuppressed inpatients, highlighting the benefit of prompt antiviral therapy.

Key Points

To evaluate the clinical manifestations, risk factors for adverse outcomes, and antiviral treatment efficacy among immunosuppressed inpatients diagnosed with influenza.
Analyzed 111 immunosuppressed inpatients confirmed positive for influenza virus via RT-PCR between the 2015 and 2020 influenza seasons in Beijing, China.
Evaluated clinical presentations, outcomes of standard versus double-dose or combination neuraminidase inhibitor regimens, and conducted univariate and multivariate logistic regression analyses to identify independent prognostic predictors.
The predominant immunosuppressive conditions were malignancies undergoing chemotherapy (87.4%, 97/111) and hematopoietic stem cell transplantation (23.4%, 26/111); overall, 14.4% (16/111) required ICU admission and 9.9% (11/111) died, while only 2.7% (3/111) had received seasonal influenza vaccination.
Multivariate logistic regression revealed that dyspnea, co-infection, and the lack of antiviral treatment within 48 hours independently predicted ICU admission, while dyspnea and altered mental status independently predicted mortality.
Combination therapy and double-dose neuraminidase inhibitors did not significantly reduce rates of ICU admission or mortality compared to standard therapy.

Cite This Study

Liu et al. (2024) studied this question.

synapsesocial.com/papers/6a87376c36c36f97809edf60 https://doi.org/10.22541/au.170664526.62144573/v1

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Implication

Cohort study identifies risk factors for critical illness and death from influenza in immunosuppressed inpatients, highlighting the benefit of prompt antiviral therapy.

Clinical characteristics, risk factors and antiviral treatment of Influenza in immunosuppressed inpatients in Beijing, 2015-2020

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Key Points

Cite This Study

Clinical characteristics, risk factors and antiviral treatment of Influenza in immunosuppressed inpatients in Beijing, 2015-2020

Discussion

Member takes

Implication

Key Points

Cite This Study

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