Augmented efficiency of regional myocardial work by ouabain

J. Kedem; Peter M. Scholtz; H. R. Weiss

doi:10.1093/cvr/25.11.916

November 1, 1991Cardiovascular Research

Augmented efficiency of regional myocardial work by ouabain

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Why the study?

Does intravenous ouabain improve regional myocardial efficiency in open-chest anesthetized dogs?

Key Points

To evaluate the impact of ouabain infusion on regional myocardial mechanics and corresponding regional oxygen consumption.
Administered intravenous ouabain (7 µg·kg⁻¹·min⁻¹) to 10 open-chest anesthetized dogs weighing approximately 20 kg.
Measured regional segment length via ultrasonic crystals, force development with strain gauges, coronary blood flow using radioactive microspheres, and oxygen saturation via microspectrophotometry.
Ouabain increased regional myocardial segment work from 5,291 (SEM 1,067) to 8,916 (2,338) mm·g⁻¹·min⁻¹, which exceeded the rise in regional oxygen consumption from 6.33 (0.75) to 8.54 (0.75) ml O2·min⁻¹·100 g⁻¹.
Myocardial shortening increased more than peak force development (+76% vs +38%), shifting the length-force loop upward and to the right.

Structured PICO

Does intravenous ouabain improve regional myocardial efficiency in open-chest anesthetized dogs?

P

Population

10 open-chest anesthetized dogs, weight about 20 kg

I

Intervention

Intravenous infusion of ouabain (7 micrograms.kg-1.min-1)

C

Comparator

Baseline (pre-infusion)

O

Outcome

Regional myocardial efficiency (expressed as regional work/regional myocardial MVO2)surrogate

In an open-chest dog model, intravenous ouabain increased the regional efficiency of myocardial contraction by increasing regional myocardial segment work to a greater extent than regional myocardial oxygen consumption.

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Implication

Hypothesis-generating in canine model; leaves open translation to human myocardial efficiency.

Abstract

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Cite This Study

Kedem et al. (1991) studied this question.

synapsesocial.com/papers/6a8737ad724d0a1274155181 https://doi.org/10.1093/cvr/25.11.916

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Augmented efficiency of regional myocardial work by ouabain

Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Augmented efficiency of regional myocardial work by ouabain

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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