Why the study?
Does higher heart rate increase myocardial ouabain uptake and susceptibility to cardiotoxicity in dogs?
Population
Sedated and anaesthetized open-chest dogs
Comparison
High heart rate during intravenous 3H-ouabain… vs Lower heart rate (90 ± 14 beats/min)
Design
Preclinical
Follow-up
30 min
Authors
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May increase ouabain cardiotoxicity risk at higher rates; leaves open relevance to human digitalis therapy.
Does higher heart rate increase myocardial ouabain uptake and susceptibility to cardiotoxicity in dogs?
Higher heart rate increases myocardial ouabain uptake and susceptibility to ouabain-induced ventricular tachycardia in a canine model.
Lloyd et al. (1978) studied this question.
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