Why the study?
Does phytonadione administration improve clinical outcomes or cost-effectiveness compared to conservative management in patients with excessive anticoagulation (INR > 6.0)?
Population
248 patients with an international normalized ratio of greater than 6.0 in a group model health maintenance…
Comparison
Phytonadione (vitamin K1) administration vs Conservative management
Design
Cohort
Authors
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Conservative management may be cost-effective for INR 6-10; leaves open need for randomized confirmation.
Does phytonadione administration improve clinical outcomes or cost-effectiveness compared to conservative management in patients with excessive anticoagulation (INR > 6.0)?
Conservative management by temporarily holding warfarin is a viable and cost-effective option for patients with moderate elevations of INR (6.0-10.0), challenging the necessity of routine phytonadione administration.
Lousberg et al. (1998) studied this question.
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