A novel integrative analysis method enables the assessment of total Ca2+ handling, futile Ca2+ cycling, and Ca2+ reactivity of Emax in a beating left ventricle.
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Animal data quantify variable Ca2+ handling; novel integrative method extends futile cycling assessment in beating LV but leaves clinical translation open.
We have aimed to assess total Ca 2+ handling in excitation-contraction coupling in a beating left ventricle (LV). Our newly developed integrative analysis method utilizes the internal Ca 2+ recirculation fraction (RF), O 2 consumption ( Vo 2 ) for Ca 2+ handling, and O 2 cost of Emax (contractility index) of the LV. We have obtained the O 2 cost of Emax from Vo 2 measured at different contractility levels, and have combined the cost with RF calculated from the beat-constant of the exponential decay component of the postextrasystolic potentiation. Our method calculates the unknown total Ca 2+ handling from the RF and the " Ca 2+ handling Vo 2 ". The calculated total Ca 2+ handling fell between 30 and 110 μmol/kg, depending on contractility and pathological conditions. The present method also enable's reasonable assessment of futile Ca 2+ cycling and of the Ca 2+ reactivity of Emax. Our method seems useful to better understanding of the pathophysiology of total Ca 2+ handling in a beating heart.
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Araki et al. (2001) studied this question.
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