Why the study?
Major clinical events observed in COVID-19 patients, such as high blood pressure, thrombosis, and pulmonary embolism, suggested that the virus targets the endothelium.
This review highlights the role of endothelial dysfunction in the pathogenesis of COVID-19 complications such as thrombosis and pulmonary embolism.
Endothelium is key COVID-19 target; hypothesis-generating and leaves open whether this informs therapy or trial design.
The symptoms most commonly reported by patients affected by coronavirus disease 2019 (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g. high blood pressure, thrombosis, pulmonary embolism) seem to suggest that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ of COVID-19.
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Sardu et al. (2020) studied this question.
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