Population
Primary cultures of neonatal ventricular cardiomyocytes from Lewis Rattus norvegicus
Comparison
Electrical stimulation in the presence of the… vs Electrical stimulation without blebbistatin…
Design
Preclinical
Authors
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Should not alter clinical pacing or regenerative strategies; hypothesis-generating for electrical modulation of human cardiomyocyte fate.
Electrical signaling directly regulates cardiomyocyte gene expression and development independently of the mechanical contractions it evokes.
Martherus et al. (2010) studied this question.
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