Key result
Experimental cardiac tissue monolayer model maps strength-duration curves and cellular contraction during electrical stimulation.
This study establishes an experimental protocol for uniform field stimulation of cultured myocardial cells to investigate fundamental electrical properties.
Monolayer model enables cardiac electrostimulation studies; leaves open translation to clinical pacing or device optimization.
This paper reports on the use of a cardiac tissue monolayer model in the investigation of some of the fundamental electrical properties of cardiac muscle. The response of cardiac tissue to increasing levels of electrical stimulus is investigated and the strength-duration curve for rectangular waveform stimulation is measured. An experimental protocol is established which provides for uniform field stimulation of the cells, and allows the cellular response (contraction) to be recorded.
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Mitchell et al. (1992) studied Cultured myocardial cells. Electrical stimulation was evaluated on Strength-duration curve and cellular response (contraction). An experimental protocol using a cardiac tissue monolayer model was established to measure the strength-duration curve and record cellular contraction in response to uniform field electrical stimulation.
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