Genetic Aspects of Perthes' Disease

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Population

412 children with Perthes' disease and their relatives

Design

Cohort

Authors

Discussion

May inform familial recurrence counseling in Perthes' disease; leaves open validation of heritability estimates in prospective cohorts.

Population

412 children with Perthes' disease (87 boys and 58 girls from one series, combined with 223 boys and 44 girls from Gray et al.) and their relatives

Comparator

General population of the same sex

Outcome

Incidence of Perthes' disease in relatives compared to the general population and heritability estimates

Perthes' disease exhibits features of multifactorial inheritance with high heritability (84%) and low environmental influence.

D. J. HALL (1986) studied this question.

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