Population
Mice models of fetal development and pressure overload-induced hypertrophy and heart failure
Design
Preclinical
Authors
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Distal Nppa enhancers are essential in disease models; leaves open their utility as therapeutic targets in human HF.
Distinct distal regulatory sequences control the fetal ventricular activity and the disease-induced reactivation of the Nppa gene, indicating that proximal promoters alone are insufficient models for ventricular gene activity.
Horsthuis et al. (2008) studied this question.
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