What question did this study set out to answer?

To visualize the intracellular localization and export pathway of elastin in vascular cells using immuno electron microscopy.

January 1, 1981Connective Tissue Research

Immuno Electron Microscopic Studies on Cells Synthesizing Elastin

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To visualize the intracellular localization and export pathway of elastin in vascular cells using immuno electron microscopy.
Examined embryonic chick and hamster aortic tissues using electron microscopy.
Etched plastic thin sections with a dilute solution of benzene, methanol, and ethanol prior to labeling with ferritin-conjugated, elastin-specific antibodies.
Ferritin-labeled antibodies specifically stained intracellular vesicles in both smooth muscle and endothelial cells, alongside extracellular elastin fibers.
Ferritin-positive vesicles displayed a lipid-laden appearance in chick cells and fused with the plasma membrane to discharge elastin into the extracellular space in both species.

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Implication

Ultrastructural study demonstrates vesicular secretion of elastin in embryonic aorta cells, indicating extracellular discharge occurs via plasma membrane fusion.

Cite This Study

Damiano et al. (1981) studied this question.

synapsesocial.com/papers/6a87a9fb420edc2ae9c4d5b5 https://doi.org/10.3109/03008208109152372

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Implication

Ultrastructural study demonstrates vesicular secretion of elastin in embryonic aorta cells, indicating extracellular discharge occurs via plasma membrane fusion.

Immuno Electron Microscopic Studies on Cells Synthesizing Elastin

Key Points

Discussion

Implication

Cite This Study

Immuno Electron Microscopic Studies on Cells Synthesizing Elastin

Key Points

Discussion

Implication

Cite This Study

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