Key result
Rat aortic allografts increase elastin mRNA expression that shifts to the neointima by 20 days.
Why the study?
The role of elastin in intimal thickening in arteries of transplanted organs has not been defined.
Population
Adult rats with abdominal aortic transplant between 2 strains disparate for MHC class I antigens
Comparison
Aortic allografts vs normal aortic wall of adult rats
Design
Preclinical animal model study
Follow-up
Up to more than 20 days
Authors
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Elastin upregulation may mark early vascular remodeling in allografts; hypothesis-generating for matrix-targeted interventions in transplant arteriosclerosis.
Acute arterial graft rejection in a rat model induces a transient increase in elastin mRNA in medial smooth muscle cells, followed by expression in neointimal cells, suggesting a role in transplant-related intimal thickening.
Isik et al. (1994) studied Acute arterial graft rejection. Abdominal aortic transplant (allograft) vs. Normal aortic wall was evaluated on Elastin gene expression. Aortic allografts in rats exhibited increased elastin mRNA in medial vascular smooth muscle cells at 7 days post-transplantation, shifting to juxtaluminal cells of the neointima after 20 days.
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