Why the study?
Are high concentrations of HDL-associated SAA and SP-B associated with cardiac events and mortality in patients with type 2 diabetes on hemodialysis?
Population
1152 patients with type 2 diabetes mellitus on hemodialysis participating in The German Diabetes Dialysis…
Comparison
High concentrations of HDL-associated serum… vs Lower concentrations of SAA(HDL) and SP-B(HDL)
Design
Cohort
Authors
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May signal higher risk beyond HDL-C in diabetic hemodialysis; leaves open causal role and intervention targets.
Are high concentrations of HDL-associated SAA and SP-B associated with cardiac events and mortality in patients with type 2 diabetes on hemodialysis?
In patients with type 2 diabetes on hemodialysis, altered HDL protein composition (higher SAA and SP-B) is associated with increased cardiovascular risk and mortality independent of HDL cholesterol levels.
Kopecky et al. (2014) studied this question.
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