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October 30, 2021Journal of the American Heart AssociationOpen Access

Admission Glucose Levels and Associated Risk for Heart Failure After Myocardial Infarction in Patients Without Diabetes

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Why the study?

Information on outcomes other than mortality associated with dysglycemia at acute myocardial infarction is less well explored in patients without diabetes from a long-term perspective.

Does elevated admission glucose increase the risk of long-term complications in patients with AMI without diabetes?

Population

45 468 patients without diabetes with AMI and admission glucose <=11 mmol/L (<=198 mg/dL)

Comparison

Categorized admission glucose levels vs reference glucose 4.0-6.0 mmol/L (72-109 mg/dL)

Design

Nationwide registry-based cohort study

Follow-up

Mean 3.3+/-1.7 years

Discussion

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Member takes

Overview

Admission hyperglycemia may stratify long-term risk after AMI without diabetes; leaves open whether glucose-targeted interventions improve outcomes.

Structured PICO

Does elevated admission glucose increase the risk of long-term complications in patients with AMI without diabetes?

P
Population
45,468 patients without diabetes with acute myocardial infarction (AMI) and admission glucose ≤11 mmol/L (≤198 mg/dL) registered in the SWEDEHEART registry.
I
Intervention
Elevated admission glucose levels (7.8-11.0 mmol/L [140-198 mg/dL])
C
Comparator
Normal admission glucose levels (4.0-6.0 mmol/L [72-109 mg/dL])
O
Outcome
Long-term outcomes including acute myocardial infarction, heart failure, stroke, renal failure, and deathhard clinical

Elevated admission glucose levels in non-diabetic patients with AMI are associated with an increased long-term risk of heart failure, renal failure, and death, highlighting its utility in risk stratification.

Cite This Study

A 2021 study studied this question.

synapsesocial.com/papers/6a87b1e53f31f6b699bb5109https://doi.org/10.1161/jaha.121.022667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Basal glucometabolic status has an impact on long‐term prognosis following an acute myocardial infarction in non‐diabetic patients2003 · 55 citations
  2. 2Impaired Glucose Tolerance or Newly Diagnosed Diabetes Mellitus Diagnosed during Admission Adversely Affects Prognosis after Myocardial Infarction: An Observational Study2015 · 66 citations
  3. 3Prevalence and relevance of abnormal glucose metabolism in acute coronary syndromes: insights from the PLATelet inhibition and patient Outcomes (PLATO) trial2019 · 15 citations
  4. 4Heart Failure Association of the European Society of Cardiology Update on Sodium–Glucose Co-Transporter 2 Inhibitors in Heart Failure2020 · 84 citations
  5. 5Association between prediabetes and risk of chronic kidney disease: a systematic review and meta‐analysis2016 · 155 citations