Incorporation studies have been carried out with [Me-13C]methionine and aromatic compounds labelled with 14C or 2H. Evidence is presented that 4,6-dihydroxy-3,5-dimethyl-2-(1-methyl-2-oxopropyl)benzaldehyde (13) is the first enzyme-free aromatic intermediate in the biosynthesis of citrinin in P. citrinum, and that all three methylations take place on the polyketide synthetase complex.
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Barber et al. (1981) studied this question.
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