The study suggests that the triadic junction may not function as an electrical coupling based on the accessibility of the T-system surface.
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Questions triadic junction electrical coupling in muscle; leaves open T-system accessibility role in excitation-contraction coupling.
Ferritin and Imferon molecules were introduced as tracers inside "skinned" muscle fibers to test which part of the triadic junction gap is freely exchangeable with the sarcoplasm. At least 50% of the T-system surface is freely accessible from the sarcoplasm. Of the remainder, 30% of the total T-system surface is covered by the junctional feet, and 20% in the center of the junction may or may not be accessible. The possibility is discussed that the triadic junction may not function as an electrical coupling.
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Clara Franzini‐Armstrong (1971) studied this question.
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