Removal and Absorption of Antibiotics in Patients with Renal Failure Undergoing Peritoneal Dialysis

Article1 March 1967Removal and Absorption of Antibiotics in Patients with Renal Failure Undergoing Peritoneal DialysisTetracycline, Chloramphenicol, Kanamycin, and ColistimethatePAUL A. GREENBERG, M.D., JAY P. SANFORD, M.D.PAUL A. GREENBERG, M.D.Search for more papers by this author, JAY P. SANFORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGram-negative bacterial infections frequently complicate the management of patients undergoing peritoneal dialysis for renal failure. All require immediate and vigorous antibiotic therapy. Because the antibiotics recommended to effectively treat such infections frequently have toxic side effects, the dosage and frequency of administration of these agents become a critical factor in the care of uremic patients.The work of Kunin and associates (1-3) has provided valuable information regarding the dosage schedule of many of the antibiotics commonly used in patients with impaired renal function. In addition, these authors presented some data on the removal of antibiotics by hemodialysis. In recent years...References1. KUNINREESMERRILLFINLAND CMSBJPM: Persistence of antibiotics in blood of patients with acute renal failure. I. Tetracycline and chlortetracycline. J. Clin. Invest. 38: 1487, 1959. CrossrefMedlineGoogle Scholar2. KUNINGLAZKOFINLAND CMAJM: Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis. Ibid., p. 1498. Google Scholar3. 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NORDHOEPRICH NMPD: Polymyxin B and colistin. A critical comparison. New Eng. J. Med. 270: 1030, 1964. CrossrefMedlineGoogle Scholar51. PERKINS RL: Apnea with intramuscular colistin therapy. JAMA 190: 421, 1964. CrossrefMedlineGoogle Scholar52. PARISIKAPLAN AFMH: Apnea during treatment with sodium colistimethate. JAMA 194: 298, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, TexasFrom the Department of Internal Medicine, the University of Texas Southwestern Medical School, and Parkland Memorial Hospital, Dallas, Tex.These studies were supported in part by the Warner-Lambert Research Institute, Research Affiliate of Warner-Chilcott Laboratories, Morris Plains, N. J.Dr. Greenberg was the recipient of a postdoctoral traineeship under training grant T1-A1-30, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Jay P. Sanford, M.D., Department of Internal Medicine, the University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Tex. 75235. 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GOODWIN, M.D., ELI A. FRIEDMAN, M.D.Medical management of chronic renal failureAbsorption of antibiotics during peritoneal dialysis in patients with renal failureGeneral Considerations Concerning the Penicillins, Streptomycin and Allied Drugs, and the TetracyclinesGeneral Considerations Concerning Chloramphenicol, Erythromycin and Allied Drugs, the Polymyxins, Bacitracin, Vancomycin, Ristocetin, Cycloserine, the Cephalosporins, the Chemotherapeutic Drugs, and the Antimycotic DrugsA Guide to Use of Antibiotics in Patients with Renal Disease A Table of Recommended Doses and Factors Governing Serum LevelsCALVIN M. KUNIN, M.D., F.A.C.P. 1 March 1967Volume 66, Issue 3Page: 465-479KeywordsAntibioticsChloramphenicolGram negative bacterial infectionsHospital medicineInfectious diseasesMedical dialysisPatientsPeritoneal dialysisRenal critical careRenal failure Issue Published: 1 March 1967 Copyright & PermissionsCopyright ©, 1967, by The American College of PhysiciansPDF downloadLoading ...