Why the study?
The importance of myocardial dysfunction in sickle cell disease is debated, and data on left ventricular global longitudinal strain in this setting are rare and conflicting.
Is left ventricular global longitudinal strain (LV-GLS) abnormal in adults with sickle cell disease compared to healthy controls?
Population
37 adult patients with SCD and 34 age- and sex-matched healthy controls
Comparison
Patients with SCD vs age- and sex-matched healthy controls
Design
Prospective study
Authors
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Speckle-tracking strain may detect subclinical LV dysfunction missed by LVEF in SCD; leaves open whether it improves risk stratification or guides therapy.
Is left ventricular global longitudinal strain (LV-GLS) abnormal in adults with sickle cell disease compared to healthy controls?
LV-GLS is reduced in a subset of adult patients with sickle cell disease, suggesting it may be a useful tool for detecting early myocardial dysfunction, though its clinical impact requires further study.
Morissens et al. (2020) studied this question.
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