Key result
Pediatric sickle cell disease is linked to increased LV stiffness, with ~44% showing LV dilatation.
Why the study?
Cardiac dysfunction timing and diastolic function have not been comprehensively analyzed in children with sickle cell disease.
Does sickle cell disease affect left ventricular diastolic function in pediatric patients compared to healthy controls?
Population
156 pediatric patients including 73 with sickle cell disease and 81 controls
Comparison
Pediatric sickle cell disease patients vs healthy controls
Design
Cross-sectional echocardiographic study
Authors
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May support early echocardiographic monitoring in pediatric SCD; leaves open prognostic value and intervention thresholds.
Cross-Sectional (n=156)
Does sickle cell disease affect left ventricular diastolic function in pediatric patients compared to healthy controls?
Pediatric patients with sickle cell disease exhibit early signs of cardiac involvement, including increased left ventricular stiffness and hypertrophy, highlighting the utility of tissue Doppler imaging for early detection.
Zilberman et al. (2007) conducted a cross-sectional in Pediatric sickle cell disease (n=156). Sickle cell disease vs. Controls was evaluated on Left ventricular diastolic function (volumes, mitral inflow, and tissue Doppler indices). Pediatric sickle cell disease was associated with increased left ventricular stiffness, with 32 of 73 SCD patients exhibiting left ventricular dilatation and 11 exhibiting hypertrophy.
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